Bieber Th.
Atopic dermatitis 2.0: from the clinical phenotype to the molecular taxonomy and stratified medicine.
Allergy 2012;67:1475–1482.
Abstract
Atopic dermatitis (AD) is a paradigmatic inflammatory chronic skin disease. As for other chronic skin diseases, (i) the spectrum of the clinical phenotype and severity as well as (ii) the genetic background and (iii) the underlying mechanisms strongly suggest a high degree of pathophysiological heterogeneity yet leading to a similar clinical pattern, that is, the eczematous skin lesion, but showing distinct progression patterns. This review suggests to exploit the recent knowledge about AD for a novel approach proposing a tentative first molecular taxonomy of this disease based on the genotype and endophenotype. The consequences in terms of personalized prevention and management are delineated.
Πολύ ενδιαφέρουσα ανασκόπηση με θέμα την προσέγγιση σύνθετων κλινικών νοσημάτων από την οπτική γωνία της εξατομικευμένης ιατρικής (personalized medicine), στην συγκεκριμένη περίπτωση της Ατοπικής Δερματίτιδας.
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http://onlinelibrary.wiley.com/doi/10.1111/all.12049/full