Component-resolved diagnosis in pediatrics.
ISRN Pediatr. 2012;2012:806920.
Epub 2012 Aug 5. PubMed PMID: 22919510;
Component resolved diagnosis is a new concept in the investigation of pediatric allergic disease. The aim of the present paper is to review the available data on component resolved diagnosis with respect to implications for investigation of children with allergic disease. In most conditions head-to-head comparisons of component resolved diagnosis with traditional IgE testing have not been performed. Rather than alternatives the molecular methods should be seen as adjuncts to the cheaper traditional specific IgE tests. It may be appropriate to determine IgE antibodies to components as part of the diagnostic work-up in selected cases of peanut and birch pollen allergy and in hymenoptera allergy. However, cost benefit analyses of component resolved diagnosis compared with traditional work-up of allergy are needed. Prospectively planned protocols for assessment of the extent to which component resolved diagnosis may be able to improve the selection of children to immunotherapy and, thus, the efficacy of immunotherapy, are needed. Finally, studies of component resolved diagnosis with microarray technology in screening panels with hundreds of components should be undertaken before it can be determined to which extent such panel screening, if at all, may be helpful in children.
Σύντομη και περιεκτική εισαγωγή στις βασικές αρχές, τα πλεονεκτήματα και τους περιορισμούς στην διαγνωστική ακρίβεια και την σχέση κόστους-αποτελέσματος της στοιχειακής μοριακής διάγνωσης στην διερεύνηση των αλλεργικών νοσημάτων.
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Copyright © 2012 Ole D.Wolthers.
This is an open access article distributed under the Creative Commons Attribution License.