ΕΠΙΣΤΗΜΟΝΙΚΗ ΕΝΗΜΕΡΩΣΗ

Pavord ID, Korn S, Howarth P, Bleecker ER, Buhl R, Keene ON, Ortega H, Chanez P. Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial. Lancet. 2012 Aug 18;380(9842):651-9. Summary Background Some patients with severe asthma have recurrent asthma exacerbations associated with eosinophilic airway inflammation. Early studies suggest that inhibition of eosinophilic airway inflammation with mepolizumab—a monoclonal antibody …

Busse W, Buhl R, Fernandez Vidaurre C, Blogg M, Zhu J, Eisner MD, Canvin J. Omalizumab and the risk of malignancy: results from a pooled analysis. J Allergy Clin Immunol. 2012 Apr;129(4):983-9.e6. Abstract BACKGROUND: Since initial registration, the omalizumab clinical trial database has expanded considerably, with a doubling of patients exposed in the clinical trial environment. Previous pooled data (2003) …

Ram FSF (2011). Self-Injectable Adrenaline for Anaphylactic Emergencies: Effectiveness of Epipen and Anapen – Are they Fit for Purpose – Evidence to Date. J Aller Ther 3:116. doi:10.4172/2155-6121.1000116. Extract : Life-threatening anaphylactic emergencies are largely unpredictable. Adrenaline is widely accepted as first-line therapy for anaphylaxis, due to its physiological effects in reversing symptoms of anaphylaxis and with studies showing both …

Hashizume H. Recent progress of elucidating the mechanisms of drug hypersensitivity. Asia Pac Allergy. 2012 Jul;2(3):203-9. Abstract Recent technical approaches to investigating drug hypersensitivity have provided a great deal of information to solve the mechanisms that remain poorly understood. First, immunological investigations and in silico analysis have revealed that a novel interaction between T cells and antigen-presenting cells, namely the …

Thomas WR. House dust allergy and immunotherapy. Hum Vaccin Immunother. 2012 Oct 1;8(10). Abstract. HDM allergy is associated with asthma, allergic rhinitis and atopic dermatitis. In many countries childhood asthma is predominantly found in HDM-allergic children with their probability of developing disease being proportional to their IgE antibody titers and the early development of Th2 responses. While the pathogenesis is …

McWilliams L, Mousallem T, Burks W. Future therapies for food allergy. Hum Vaccin Immunother. 2012 Oct 1;8(10). Abstract. Food allergy affects 3.9% of US children and is increasing in prevalence. The current standard of care involves avoidance of the triggering food and treatment for accidental ingestions. While there is no current curative treatment, there are a number of therapeutic strategies …

Σχολιασμός της συστηματικής ανασκόπησης και μετα-ανάλυσης των Huang , Li , και Chen σχετικά με την αποτελεσματικότητα της γ-σφαιρίνης (IVIg) στην θεραπευτική αντιμετώπιση της τοξικής επιδερμικής νεκρόλυσης (TEN) : Walsh S, Creamer D. IVIg in TEN: time to re-evaluate the efficacy of intravenous immunoglobulin in the management of toxic epidermal necrolysis. Br J Dermatol. 2012 Aug;167(2):230-1. « Although the use …

Σχολιασμός της συστηματικής ανασκόπησης και μετα-ανάλυσης των Huang , Li , και Chen σχετικά με την αποτελεσματικότητα της γ-σφαιρίνης (IVIg) στην θεραπευτική αντιμετώπιση της τοξικής επιδερμικής νεκρόλυσης (TEN) : Walsh S, Creamer D. IVIg in TEN: time to re-evaluate the efficacy of intravenous immunoglobulin in the management of toxic epidermal necrolysis. Br J Dermatol. 2012 Aug;167(2):230-1. « Although the use …

Sajić D, Asiniwasis R, Skotnicki-Grant S. A look at epidermal barrier function in atopic dermatitis: physiologic lipid replacement and the role of ceramides. Skin Therapy Lett. 2012 Jul;17(7):6-9. Abstract. This review summarizes and discusses the role and efficacy of moisturizers, particularly the more recently introduced ceramide-based formulations, in the skin care regimen of patients with both active and quiescent atopic …

Στα πλαίσια της πολύπλευρης εκπαιδευτικής της δραστηριότητας η Ευρωπαϊκή εταιρεία αναπνευστικών νοσημάτων (European Respiratory Society) προσφέρει ελεύθερα στο επιστημονικό κοινό μία σειρά διαδικτυακών ομιλιών και παρουσιάσεων από διακεκριμένους ερευνητές: ERS CME ONLINE. LEARN FROM THE EXPERTS. 20+ INTERACTIVE ONLINE MODULES. VIDEO INTERVIEWS AND DEBATES. http://www.ers-education.org/cmeOnline/selection.aspx Θέματα με ιδιαίτερο ενδιαφέρον για τον αλλεργιολόγο : Chronic Airway inflammation : Upper and lower …