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Πρόοδοι στην Αλλεργιολογία για το έτος 2012

Όπως είθισται στην διεθνή επιστημονική κοινότητα, το τέλος κάθε χρονιάς προσφέρει μία ευκαιρία για ανασκόπηση των επιστημονικών επιτευγμάτων του έτους που παρήλθε.

Μπορείτε να συμβουλευθείτε τις αντίστοιχες προόδους για το 2012 από την οπτική γωνία της σημαντικής περιoδικής έκδοσης «The Journal of Allergy and Clinical Immunology» :

Szefler SJ.

Advances in pediatric asthma in 2012: Moving toward asthma prevention.

J Allergy Clin Immunol. 2013 Jan;131(1):36-46.

Abstract

Last year’s “Advances in pediatric asthma: moving forward” concluded the following: “Now is also the time to utilize information recorded in electronic medical records to develop innovative disease management plans that will track asthma over time and enable timely decisions on interventions in order to maintain control that can lead to disease remission and prevention.” This year’s summary will focus on recent advances in pediatric asthma on modifying disease activity, preventing asthma exacerbations, managing severe asthma, and risk factors for predicting and managing early asthma, as indicated in Journal of Allergy and Clinical Immunology publications in 2012. Recent reports continue to shed light on methods to improve asthma management through steps to assess disease activity, tools to standardize outcome measures in asthma, genetic markers that predict risk for asthma and appropriate treatment, and interventions that alter the early presentation of asthma to prevent progression. We are well on our way to creating a pathway around wellness in asthma care and also to use new tools to predict the risk for asthma and take steps to not only prevent asthma exacerbations but also to prevent the early manifestations of the disease and thus prevent its evolution to severe asthma.

http://www.jacionline.org/article/S0091-6749%2812%2901789-7/fulltext

Apter AJ.

Advances in adult asthma diagnosis and treatment in 2012: Potential therapeutics and gene-environment interactions.

J Allergy Clin Immunol. 2013 Jan;131(1):47-54.

Abstract

In the Journal of Allergy and Clinical Immunology in 2012, research reports related to asthma in adults clustered around mechanisms of disease, with a special focus on their potential for informing new therapies. There was also consideration of the effect of the environment on health from pollution, climate change, and epigenetic influences, underlining the importance of understanding gene-environment interactions in the pathogenesis of asthma and response to treatment.

http://www.jacionline.org/article/S0091-6749%2812%2901835-0/fulltext

Sicherer SH, Leung DY.

Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2012.

J Allergy Clin Immunol. 2013 Jan;131(1):55-66.

Abstract

 This review highlights some of the research advances in anaphylaxis; hypersensitivity reactions to foods, drugs, and insects; and allergic skin diseases that were reported in the Journal in 2012. Studies support an increase in peanut allergy prevalence in children and exposure to the antibacterial agent triclosan and having filaggrin (FLG) loss-of-function mutations as risk factors for food sensitization. The role of specific foods in causing eosinophilic esophagitis is elucidated by several studies, and microRNA analysis is identified as a possible noninvasive disease biomarker. Studies on food allergy diagnosis emphasize the utility of component testing and the possibility of improved diagnosis through stepped approaches, epitope-binding analysis, and bioinformatics. Treatment studies of food allergy show promise for oral immunotherapy, but tolerance induction remains elusive, and additional therapies are under study. Studies on anaphylaxis suggest an important role for platelet-activating factor and its relationship to the need for prompt treatment with epinephrine. Insights on the pathophysiology and diagnosis of non-IgE-mediated drug allergy are offered, with novel data regarding the interaction of drugs with HLA molecules. Numerous studies support influenza vaccination of persons with egg allergy using modest precautions. Evidence continues to mount that there is cross-talk between skin barrier defects and immune responses in patients with atopic dermatitis. Augmentation of the skin barrier with reduction in skin inflammatory responses will likely lead to the most effective intervention in patients with this common skin disease.

http://www.jacionline.org/article/S0091-6749%2812%2901782-4/fulltext

Επί του παρόντος η πρόσβαση στα άρθρα είναι ελεύθερη από το website του εκδότη.

Να υπενθυμίσουμε πως η πρόσβαση στο «The Journal of Allergy and Clinical Immunology» είναι ελεύθερη για τα μέλη της ΕΑΑΚΑ μετά από σύνδεση στην ιστοσελίδα των μελών.

Καλή Χρονιά με υγεία και ευτυχία για το 2013.

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