Fleischer DM, Perry TT, Atkins D, Wood RA, Burks AW, Jones SM, Henning AK, Stablein D, Sampson HA, Sicherer SH.
Allergic reactions to foods in preschool-aged children in a prospective observational food allergy study.
Pediatrics. 2012 Jul;130(1):e25-32.
Abstract
OBJECTIVE:
To examine circumstances of allergic reactions to foods in a cohort of preschool-aged children.
METHODS:
We conducted a prospective, 5-site observational study of 512 infants aged 3 to 15 months with documented or likely allergy to milk or egg, and collected data prospectively examining allergic reactions.
RESULTS:
Over a median follow-up of 36 months (range: 0-48.4), the annualized reaction rate was 0.81 per year (367/512 subjects reporting 1171 reactions [95% confidence interval: 0.76-0.85]). Overall, 269/512 (52.5%) reported >1 reaction. The majority of reactions (71.2%) were triggered by milk (495 [42.3%]), egg (246 [21.0%]), and peanut (93 [7.9%]), with accidental exposures attributed to unintentional ingestion, label-reading errors, and cross-contact. Foods were provided by persons other than parents in 50.6% of reactions. Of 834 reactions to milk, egg, or peanut, 93 (11.2%) were attributed to purposeful exposures to these avoided foods. A higher number of food allergies (P < .0001) and higher food-specific immunoglobulin E (P < .0001) were associated with reactions.
Of the 11.4% of reactions (n = 134) that were severe, 29.9% were treated with epinephrine. Factors resulting in undertreatment included lack of recognition of severity, epinephrine being unavailable, and fears about epinephrine administration.
CONCLUSIONS:
There was a high frequency of reactions caused by accidental and nonaccidental exposures. Undertreatment of severe reactions with epinephrine was a substantial problem. Areas for improved education include the need for constant vigilance, accurate label reading, avoidance of nonaccidental exposure, prevention of cross-contamination, appropriate epinephrine administration, and education of all caretakers.
Η πρόσβαση στο άρθρο είναι ελεύθερη στο διαδίκτυο :
http://pediatrics.aappublications.org/content/130/1/e25.full
Νήπια και παιδιά προσχολικής ηλικίας με αλλεργία στο γάλα και το αυγό έχουν πιθανότητα 80 % για μία τουλάχιστον αλλεργική αντίδραση κάθε χρόνο σύμφωνα με αυτήν την πολύ ενδιαφέρουσα προοπτική μελέτη από τις Η.Π.Α.
Η από λάθος χορήγηση των αλλεργιογονικών τροφών, αλλά και η ελλιπής επιτήρηση αυτών των παιδιών από το περιβάλλον τους φαίνεται να διαδραματίζει σημαντικό ρόλο στην υψηλή συχνότητα αναφυλακτικών αντιδράσεων σε αυτόν τον πληθυσμό.
Η θεραπεία εκλογής για τις σοβαρές αναφυλακτικές αντιδράσεις, δηλαδή η αδρεναλίνη, χρησιμοποιήθηκε μόνον στο 1/3 των ασθενών με αναφυλακτικό shock.