Επιστημονική Ενημέρωση

Kerstjens HA, Engel M, Dahl R, Paggiaro P, Beck E, Vandewalker M, Sigmund R, Seibold W, Moroni-Zentgraf P, Bateman ED.  Tiotropium in Asthma Poorly Controlled with Standard Combination Therapy. N Engl J Med. 2012 Sep 2. [Epub ahead of print]. Background. Some patients with asthma have frequent exacerbations and persistent airflow obstruction despite treatment with inhaled glucocorticoids and long-acting beta-agonists …

Cicardi M, Johnston DT. Hereditary and acquired complement component 1 esterase inhibitor deficiency: a review for the hematologist. Acta Haematol. 2012;127(4):208-20. Abstract Hereditary angioedema (HAE), a rare autosomal dominant disorder, was first described in the late 19th century. The disease remained poorly understood and without therapeutic options until the latter half of the 20th century. Advances in the understanding of …

Pavord ID, Korn S, Howarth P, Bleecker ER, Buhl R, Keene ON, Ortega H, Chanez P. Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial. Lancet. 2012 Aug 18;380(9842):651-9. Summary Background Some patients with severe asthma have recurrent asthma exacerbations associated with eosinophilic airway inflammation. Early studies suggest that inhibition of eosinophilic airway inflammation with mepolizumab—a monoclonal antibody …

Busse W, Buhl R, Fernandez Vidaurre C, Blogg M, Zhu J, Eisner MD, Canvin J. Omalizumab and the risk of malignancy: results from a pooled analysis. J Allergy Clin Immunol. 2012 Apr;129(4):983-9.e6. Abstract BACKGROUND: Since initial registration, the omalizumab clinical trial database has expanded considerably, with a doubling of patients exposed in the clinical trial environment. Previous pooled data (2003) …

Ram FSF (2011). Self-Injectable Adrenaline for Anaphylactic Emergencies: Effectiveness of Epipen and Anapen – Are they Fit for Purpose – Evidence to Date. J Aller Ther 3:116. doi:10.4172/2155-6121.1000116. Extract : Life-threatening anaphylactic emergencies are largely unpredictable. Adrenaline is widely accepted as first-line therapy for anaphylaxis, due to its physiological effects in reversing symptoms of anaphylaxis and with studies showing both …

Hashizume H. Recent progress of elucidating the mechanisms of drug hypersensitivity. Asia Pac Allergy. 2012 Jul;2(3):203-9. Abstract Recent technical approaches to investigating drug hypersensitivity have provided a great deal of information to solve the mechanisms that remain poorly understood. First, immunological investigations and in silico analysis have revealed that a novel interaction between T cells and antigen-presenting cells, namely the …

Thomas WR. House dust allergy and immunotherapy. Hum Vaccin Immunother. 2012 Oct 1;8(10). Abstract. HDM allergy is associated with asthma, allergic rhinitis and atopic dermatitis. In many countries childhood asthma is predominantly found in HDM-allergic children with their probability of developing disease being proportional to their IgE antibody titers and the early development of Th2 responses. While the pathogenesis is …

McWilliams L, Mousallem T, Burks W. Future therapies for food allergy. Hum Vaccin Immunother. 2012 Oct 1;8(10). Abstract. Food allergy affects 3.9% of US children and is increasing in prevalence. The current standard of care involves avoidance of the triggering food and treatment for accidental ingestions. While there is no current curative treatment, there are a number of therapeutic strategies …

Σχολιασμός της συστηματικής ανασκόπησης και μετα-ανάλυσης των Huang , Li , και Chen σχετικά με την αποτελεσματικότητα της γ-σφαιρίνης (IVIg) στην θεραπευτική αντιμετώπιση της τοξικής επιδερμικής νεκρόλυσης (TEN) : Walsh S, Creamer D. IVIg in TEN: time to re-evaluate the efficacy of intravenous immunoglobulin in the management of toxic epidermal necrolysis. Br J Dermatol. 2012 Aug;167(2):230-1. « Although the use …

Σχολιασμός της συστηματικής ανασκόπησης και μετα-ανάλυσης των Huang , Li , και Chen σχετικά με την αποτελεσματικότητα της γ-σφαιρίνης (IVIg) στην θεραπευτική αντιμετώπιση της τοξικής επιδερμικής νεκρόλυσης (TEN) : Walsh S, Creamer D. IVIg in TEN: time to re-evaluate the efficacy of intravenous immunoglobulin in the management of toxic epidermal necrolysis. Br J Dermatol. 2012 Aug;167(2):230-1. « Although the use …