Hωσινοφιλία: Διεθνείς θέσεις ομοφωνίας iCAAL: ICON on Eosinophil Disorders, 2012

Valent P, Klion AD, Rosenwasser LJ, Arock M, Bochner BS, Butterfield JH, Gotlib J, Haferlach T, Hellmann A, Horny HP, Leiferman KM, Metzgeroth G, Matsumoto K, Reiter A, Roufosse F, Rothenberg ME, Simon HU, Sotlar K, Vandenberghe P, Weller PF, Gleich GJ.

ICON: Eosinophil Disorders.

World Allergy Organ J. 2012 Dec;5(12):174-181.

Eosinophil disorders and related syndromes are a heterogeneous group of conditions characterized by marked persistent blood eosinophilia and involvement of one or more organ systems. The hypereosinophilic (HE) state is defined by a persistent eosinophil count exceeding 1.5 × 109/L blood. Several different neoplastic, paraneoplastic, infectious, and allergic disorders may underlie HE. Eosinophil-induced organ damage with more or less typical symptoms may develop in these patients. The final diagnosis is based on clinical, molecular, and histopathologic criteria, and the presence of signs and symptoms indicative of HE-induced organ damage, the latter often manifesting as hypereosinophilic syndrome. The clinical course, prognosis, and response to certain drugs vary greatly among patients and among disease variants. During the last few years, several new markers and targets have been identified, improving diagnosis, prognostication, and therapy for patients with HE-related disorders. Moreover, several attempts have been made to establish robust disease-related criteria and a global classification for HE-related diseases. However, the pathogenesis and mechanisms of HE and of HE-induced organ damage are complex, and expert opinions remain divided.

This ICON provides an updated proposal for a global nomenclature and classification of HE-related disorders and conditions. The proposal is based on the currently available literature and merges previously published proposals and the classification proposal of the World Health Organization.

Η ομοφωνία αυτή ανακοινώθηκε αρχικά στο πρόσφατο συνέδριο του Παγκόσμιου Οργανισμού Αλλεργιολογίας στο Hyderabad της Ινδίας και στη συνέχεια δημοσιεύθηκε στο επίσημο επιστημονικό έντυπο του οργανισμού τον Δεκεμβριο του 2012. Στόχος της η διευκόλυνση του κλινικού ιατρού στην διαγνωστική και θεραπευτική προσπέλαση της υπερηωσινοφιλίας με κύριο στόχο την βελτίωση της ποιότητας ζωής των ασθενών που πάσχουν από χρόνια ηωσινοφιλικά σύνδρομα.

Η πρόσβαση είναι ελεύθερη από το website του εκδότη :

http://journals.lww.com/waojournal/Fulltext/2012/12000/ICON___Eosinophil_Disorders.1.aspx