Jolles S. The Variable in Common Variable Immunodeficiency: A Disease of Complex Phenotypes. J Allergy Clin Immunol Pract 2013;1:545-56. Abstract. Common variable immunodeficiency (CVID) is the most common and clinically most important severe primary antibody deficiency and is characterized by low levels of IgG, IgA, and/or IgM, with a failure to produce specific antibodies. This diagnostic category represents a heterogeneous …
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