Kerstjens HA, Engel M, Dahl R, Paggiaro P, Beck E, Vandewalker M, Sigmund R, Seibold W, Moroni-Zentgraf P, Bateman ED. Tiotropium in Asthma Poorly Controlled with Standard Combination Therapy. N Engl J Med. 2012 Sep 2. [Epub ahead of print]. Background. Some patients with asthma have frequent exacerbations and persistent airflow obstruction despite treatment with inhaled glucocorticoids and long-acting beta-agonists …
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