Matthew C. Bell, William W. Busse. Severe Asthma: An Expanding and Mounting Clinical Challenge. The Journal of Allergy and Clinical Immunology: In Practice, March 2013, Vol. 1, Issue 2, Pages 110-121. Although all patients with asthma have variable airflow obstruction, airway inflammation, and bronchial hyperresponsiveness, some have disease that is severe in many aspects: persistent airflow …
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